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New publication of COSM team : “In Vivo Albumin‐Binding of a C‐Functionalized Cyclam Platform for 64Cu‐PET/CT Imaging in Breast Cancer Model

Thomas Le Bihan, Cathryn H. S. Driver, Thomas Ebenhan, Nathalie Le Bris, Jan Rijn Zeevaart and Raphaël Tripier

DOI: https://doi.org/10.1002/cmdc.202000800

GluCAB-2Mal is working on the principle of tumor targeting through the Enhanced Permeability and Retention (EPR) effect as well as glucose metabolism. It was radiolabelled with 64Cu (99%), proved to be highly stable in serum and with immediate binding to serum proteins. [64Cu]Cu-GluCAB-2Mal was studied for in vivo experiments i.e. microPET/CT imaging and biodistribution analysis in an allograft E0771 breast cancer mouse model.