Home / eng-Publications / New publication in ChemPhysChem

 

New publication of team COSM : “Cationic Biphotonic Lanthanide Luminescent Bioprobes Based on Functionalized Cross‐Bridged Cyclam Macrocycles”

J. Mendy, A. T. Bui, A. Roux, J.-C. Mulatier, D. Curton, A. Duperray, A. Grichine, Y. Guyot, S. Brasselet, F. Riobé, C. Andraud, B. Le Guennic, V. Patinec, R. Tripier, M. Beyler, O. Maury

Cationic water‐soluble Eu3+ and Yb3+ complexes based on a constrained cross‐bridged cyclam macrocycle functionalized with donor‐π‐conjugated picolinate antennas has been prepared. Their spectroscopic properties were thoroughly investigated in various solvents and rationalized with the help of DFT calculations. Two‐photon microscopy imaging experiments on living T24 human cancer cells confirmed the spontaneous internalization of the probes. Images with good signal‐to‐noise have been obtained in the classical NIR  Vis configuration with Eu3+ luminescent bioprobe and in the NIR  NIR with the Yb3+ one.