Montassar Khalil, Dany Jeanne Dit Fouque, Mathieu Berchel, Aurore Fraix, Aurélien Dupont, Salvatore Sortino, Antony Memboeuf and Paul-Alain Jaffrès
Org. Biomol. Chem., 2021, 19, ; DOI: 10.1039/D1OB01078F ; hal-03282994
The incorporation of lipophilic phosphonodithioesters in phospholipids formulations generates clickable liposomes that react with amines. The kinetics of this metal free Phosphonodithioester-Amine Coupling (PAC) on liposomes in water is reported and can be classified as fast reaction with a second order rate constant of k≈ 8×102 M-1s-1. PAC reaction represents a versatile strategy to functionalize liposomes.