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New publication of COSM group : “Phosphonodithioester-Amine Coupling in water: A fast reaction to modify the surface of liposomes

Montassar Khalil,  Dany Jeanne Dit Fouque,  Mathieu Berchel, Aurore Fraix, Aurélien Dupont, Salvatore Sortino, Antony Memboeuf and Paul-Alain Jaffrès

Org. Biomol. Chem., 2021, 19, ; DOI: 10.1039/D1OB01078F ; hal-03282994

The incorporation of lipophilic phosphonodithioesters in phospholipids formulations generates clickable liposomes that react with amines. The kinetics of this metal free Phosphonodithioester-Amine Coupling (PAC) on liposomes in water is reported and can be classified as fast reaction with a second order rate constant of k≈ 8×102 M-1s-1. PAC reaction represents a versatile strategy to functionalize liposomes.