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New publication of COSM group : “Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA

Julie Pineau, Luís M. P. Lima, Carlos Platas-Iglesias, Jan Rijn Zeevaart, Cathryn H. S. Driver, Nathalie Le Bris, Raphaël Tripier

DOI: 10.1002/chem.202200942

Since the macrocyclic gold standards used in nuclear medicine are not suitable to Pd(II) coordination, its radioisotopes remain understated for radiopharmaceutical applications. The monopicolinate cyclam TE1PA presented here is a highly relevant chelator for natural and radioactive Pd, opening avenues to enrich the current palette of radiopharmaceuticals for targeted radiotherapy.