Presentation
The research group « Organic Chemistry for health and materials » from the UMR CNRS 6521 is composed by 26 persons including 13 permanent staff. The global skills of our group include both organic chemistry and coordination chemistry. In more details, we are working on organo-phosphorus chemistry, the synthesis and the coordination properties of polyazamacrocyclic compounds and the synthesis of amphiphilic compounds. Our research group is involved in numerus multidisciplinary research projects at the interface of biology and medicine (Imaging, therapy, radiopharmaceutics, nucleic acid delivery, ion channel modulation, bactericidal action) or for the development of new materials (bactericidal materials, multimeric materials & spin transition molecular materials). Our partners are academics and/or industrials. Our research group is built on two research axis: “Phosphorus, lipid & vectorization” and “azamacrocyclic compounds & coordination”.
Our web site : Team COSM’s website
Thematic
- Cationic amphiphilic compounds for nucleic acid delivery and bactericidal action

- Amphiphilic compounds for a selective modulation of ion channels

- Phosphonic acids precursors of hydrid materials


- Synthesis of macrocycles derived from tacn, cyclen, pyclen and cyclam
- Functionalization of macrocycles and / or their specific (poly) functionalization.
- LCoordination study of macrocycles with different substrates (cations or anions): (poly) phosphates, F-, Mn2+, Fe2+, Cu2+, Cu+, Zn2+ (and other transition metals), Pb2+, Bi3+, Zr4+, Y3+, In3+ and Ln3+: thermodynamics and kinetics.
- Biological studies involving complexes (in vitro and in vivo).
- Optical imaging (luminescence of Ln3+ complexes), nuclear medicine 18F, 64Cu, 67Cu, 89Zr, 90Y, 213 /212Pb-Bi and mass cytometry (all metals).
- Industrial developments of the compounds.


Team members
Research programs
Aza Macrocycles and Coordination.
- Detection of cations and anions of biological interest in a biological environment
-European Programme Project PTDC/QUI 2016-2019 : Pr Rita Delgado (Lisbon, Portugal)
- Complexation; Medical screening / Therapy / Theranostic
– ANR « SADAM » 2017-2021 « Search And Destroy with AzaMacrocycles »
– La Ligue contre le Cancer (x4): 1 Doctoral Fellowship + 3 CSIRGO programmes
– Cancéropole Grand Ouest « Emergence »
– Brittany Region (ARED financial support)
– 1 Maturation Contract with SATT Ouest Valorisation
– Networks : GDR “FrenchBic”, ‘AIM” and “GPOL”.
– Industrial contract with Guerbet (Aulnay-sous-Bois) and 1 CIFRE Fellowship
– Industrial contract with NECSA (Pretoria, South Africa)
– Industrial contract with Fluidigm (Canada, Ontario) « CYTOCHEL ».
– Industrial contract with Quéguiner Group Brest.
– Industrial contract with EasyChelators (start-up hébergée au laboratoire)
Phosphorus, Lipids & Vectorisation.
- Amphiphilic compounds : Funded by AFM, VLM, La ligue contre le Cancer, maturation contract with SATT Ouest Valorisation. Member of the GDR phosphorus network, Biogenouest, Britany regional council, Cancéropôle Grand Ouest network, “Ion channel” network, ANR, Britany regional council, la ligue contre le cancer, research program with IFREMER Brest.
- Hybrid materials: ANR HYMN (2014-2018) ; GRD Phosphorus network.
Most significant Articles
- Amphiphilic compounds
- A. Le Moignic, V. Malard, T. Benvegnu, L. Lemiègre, M. Berchel, P-A. Jaffrès, C. Baillou, M. Delost, R. Macedo, J. Rochefort, G. Lescaille, C. Pichon, F.M. Lemoine, P. Midoux, V. Mateo Preclinical Evaluation of mRNA Trimannosylated Lipopolyplexes as Therapeutic Cancer Vaccines Targeting Dendritic Cells
J. Control. Release, 2018, 278, 110-121. - Afonso, D.; Le Gall, T.; Couthon-Gourvès, H.; Grélard, A.; Prakash, S.; Berchel, M.; Kervarec,N.; Dufourc,E.J.; Montier, T.; Jaffrès, P.A. Thiol-ene click reaction applied to cationic amphiphiles: impacts on supramolecular packing and gene transfection properties.
Soft Matter, 2016, 12, 4516 – 4520. - Loizeau, D. ; Jurkiewicz, P. ; Aydogan , G. ; Philimonenko , A. ; Mahfoudhi, S. ; Hozak , P. ; Maroto, A. ; Couthon-Gourvès, H. ; Jaffrès , P.A. ; Deschamps, L. ; Giamarchi, P. ; Hof , M. Biophysical properties of cationic lipophosphoramidates: vesicle morphology, bilayer hydration and lipid mobility
Colloids and Surfaces B: Biointerfaces, 2015, 136, 192-200 - P.A. Jaffrès, C. Gajate, A.M. Bouchet, H. Couthon-Gourvès, A. Chantôme, M. Potier-Cartereau, P. Besson, P. Bougnoux, F. Mollinedo, C. Vandier, Alkyl ether lipids and lipid raft reorganization in cancer therapy
Pharmacology & Therapeutics, 2016, 165, 114-131
- A. Le Moignic, V. Malard, T. Benvegnu, L. Lemiègre, M. Berchel, P-A. Jaffrès, C. Baillou, M. Delost, R. Macedo, J. Rochefort, G. Lescaille, C. Pichon, F.M. Lemoine, P. Midoux, V. Mateo Preclinical Evaluation of mRNA Trimannosylated Lipopolyplexes as Therapeutic Cancer Vaccines Targeting Dendritic Cells
- Macrocycles & Coordination
- Camus, Z. Halime, N. Le Bris, H. Bernard, C. Platas-Iglesias, R. Tripier. Full control of the regiospecific N-functionalization of new C‑functionalized cyclam bisaminal derivatives and application to the synthesis of their TETA, TE2A and CB-TE2A analogues. Org. Chem., 2014, 79, 1885−1899.
- Rodríguez-Rodríguez, Z. Halime, L. Lima, M. Beyler, D. Deniaud, N. Le Poul, R. Delgado, C. Platas-Iglesias, V. Patinec, R. Tripier, Cyclams with ambidentate methylthiazolyl pendants for a stable, inert and selective Cu(II)/Cu(I) coordination. Inorg. Chem., 2016, 55 (2), 619–632.
- Liu, A. Nonat, M. Beyler, M. Regueiro-Figueroa, K. Nchimi Nono, O. Jeannin, F. Camerel, F. Debaene, S. Cianférani-Sanglier, R. Tripier, C. Platas-Iglesias, L. J. Charbonnière. Supramolecular Luminescent Lanthanide Capsules for Fluoride Sequestering and Sensing Angew. Chem. Int. Ed, 2014, 53, 29, 7259-7263.
- A Rodríguez-Rodríguez, M. Regueiro-Figueroa, D. Esteban-Gómez, V. Patinec, R. Tripier, G. Tircsó, F. Carniato, M. Botta and C. Platas‑Iglesias, Modulating the Water Exchange Rate in Lanthanide(III) Complexes: the Labile Capping Bond Effect at Work. Chem. Eur. J., 2017, 23,5, 1110–1117
- Materials
- Q. Evrard, Z. Chaker, M. Roger, C. M. Sevrain, E. Delahaye, M. Gallart, P.Gilliot, C. Leuvrey, J.-M. Rueff, P. Rabu,C. Massobrio, M. Boero, A. Pautrat, P.-A.Jaffrès, G. Ori, G. Rogez Layered Simple Hydroxides Functionalized by Fluorene-Phosphonic Acids: Synthesis, Interface Theoretical Insights, and Magnetoelectric Effect.
Adv. Funct. Mater., 2017, 27, 1703576 - P. Burke, N. Baghdadi, A. E. Kownacka, S. Nigam, G. S. Clemente, M. M. Al-Yassiry, J. Domarkas, M. Lorch, M. Pickles, P. Gibbs, R. Tripier, C. Cawthorne, S J. Archibald, Facile gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions: evaluation as multimodal PET/MR liver imaging agents. Nanoscale, 2015, 7(36), 14889-14896.
- Q. Evrard, Z. Chaker, M. Roger, C. M. Sevrain, E. Delahaye, M. Gallart, P.Gilliot, C. Leuvrey, J.-M. Rueff, P. Rabu,C. Massobrio, M. Boero, A. Pautrat, P.-A.Jaffrès, G. Ori, G. Rogez Layered Simple Hydroxides Functionalized by Fluorene-Phosphonic Acids: Synthesis, Interface Theoretical Insights, and Magnetoelectric Effect.